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Docks V2 0 3

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This is a General Availability (GA) release of Exchange Online PowerShell V2 module.
Please check the documentation here - https://aka.ms/exops-docs.
For issues related to the module, contact Microsoft support.

Version 3.4.0 home Branch management Demo Discovery service protocol Download and build etcd release guide Frequently Asked Questions (FAQ) Libraries and tools Logging conventions Metrics Overview Reporting bugs Tuning Benchmarks Benchmarking etcd v2.1.0 Benchmarking etcd v2.2.0 Benchmarking etcd v2.2.0-rc Benchmarking etcd v2.2.0-rc-memory. Read the Docs v: 3.0 Versions latest stable v3.0.2 3.0 v2.1.2 Downloads pdf htmlzip epub On Read the Docs Project Home Builds. Docks v2.0.3 – Have a Dock for work, a Dock for play or whatever you like. Docks Take Back your Dock! With so many fantastic applications for Mac. Weather Night Dock PRO is an application for dock stations, showing information about the current time, battery level and next alarm, but also about the weather beautiful, easily readable form. Can be used as a 'night clock'. The screen brightness can be set manually or automatically by a light sensor. Can be used as Daydream for Android 4.2+ smartphones, tablets, TV (and boxes). Dock3 (Dedicator of cytokinesis 3), also known as MOCA (modifier of cell adhesion) and PBP (presenilin-binding protein), is a large (180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins.Dock3 specifically activates the small G.

Minimum PowerShell version

3.0

There is a newer prerelease version of this module available.
See the version list below for details.

Installation Options

Copy and Paste the following command to install this package using PowerShellGet More Info

Install-Module -Name ExchangeOnlineManagement -RequiredVersion 2.0.3

You can deploy this package directly to Azure Automation. Note that deploying packages with dependencies will deloy all the dependencies to Azure Automation. Learn More

Manually download the .nupkg file to your system's default download location. Note that the file won't be unpacked, and won't include any dependencies. Learn More Ilock 3 0 2 iso.

Author(s)

Microsoft Corporation

Copyright

Docks V2 0 3

(c) 2020 Microsoft. All rights reserved.

Package Details

Owners

Tags

Cmdlets

Functions

Dependencies

This module has no dependencies.

Release Notes


---------------------------------------------------------------------------------------------
Whats new in this release:
v2.0.3 :
1. General availability of Certificate Based Authentication feature which enables using Modern Authentication in Unattended Scripting or background automation scenarios.
2. Certificate Based Authentication accepts Certificate File directly from terminal thus enabling certificate files to be stored in Azure Key Vault and being fetched Just-In-Time for enhanced security. See parameter Certificate in Connect-ExchangeOnline.
3. Connect with Exchange Online and Security Compliance Center simultaneously in a single PowerShell window.
4. Ability to restrict the PowerShell cmdlets imported in a session using CommandName parameter, thus reducing memory footprint in case of high usage PowerShell applications.
5. Get-ExoMailboxFolderPermission now supports ExternalDirectoryObjectID in the Identity parameter.
6. Optimized latency of first V2 Cmdlet call. (Lab results show first call latency has been reduced from 8 seconds to ~1 seconds. Actual results will depend on result size and Tenant environment.)
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Previous Releases:
v2.0.1 :
1. Support for App-Only Authentication -
Automate your day-to-day exchange management tasks using app-only authentication. This requires setting up an Azure AD app and connecting to Exchange using certificate. Check out https://aka.ms/AzureAD-app for setting up the App and initial onboarding experience.
Use below syntax for establishing the connection -
Connect-ExchangeOnline -AppID '' -Organization 'contoso.onmicrosoft.com' -CertificateFilePath '' -CertificatePassword ''
v1.0.1 :
1. This is the General Availability (GA) version of EXO PowerShell V2 Module. It is stable and ready for being used in production environments.
2. Get-ExoMobileDeviceStatistics cmdlet now supports Identity parameter.
3. Improved reliability of session auto-connect in certain cases where script was executing for ~50minutes and threw 'Cmdlet not found' error due to a bug in auto-reconnect logic.
4. Fixed and 'MailboxFolderUser' for easy migration of scripts.
5. Enhanced support for filters as it now supports 4 more operators - endswith, contains, not and notlike support. Please check online documentation for attributes which are not supported in filter string.
v0.4578.0 :
1. Added support for configuring Briefing Email for your organization at the user level with 'Set-UserBriefingConfig' and 'Get-UserBriefingConfig' cmdlets.
2. Support for session cleanup using Disconnect-ExchangeOnline cmdlet. This cmdlet is V2 equivalent of 'Get-PSSession | Remove-PSSession'. In addition to cleaning up session object and local files, it also removes access token from cache which is used for authenticating against V2 cmdlets.
3. You can now use FolderId as identity parameter in Get-ExoMailboxFolderPermission. You can get folderId using Get-MailboxFolder cmdlet. Below are the supported syntax for getting folder permissions -
a. Get-MailboxFolderPermission -Identity :
b. Get-MailboxFolderPermission -Identity :
4. Improved reliability of Get-ExoMailboxStatistics cmdlet as certain request routing errors which led to failures have been resolved
5. Optimized memory usage when session is created by re-using any existing module with a new session instead of creating a new one every time session is imported
v0.4368.1 :
1. Added support for Exchange Online Protection (EOP) cmdlets using 'Connect-IPPSSession' cmdlet
2. Hide announcement banner using 'ShowBanner' switch. Default value of this switch is $true. Use below syntax to hide the banner
'Connect-ExchangeOnline -ShowBanner:$false'
3. Terminate cmdlet execution on client exception
4. RPS contained various Complex data types which was consciously not supported in EXO cmdlets for improving the performance. Differences in non-complex>FileList

Version History

VersionDownloadsLast updated
2.0.4-Preview2 527 9/22/2020
2.0.3 (current version) 13,148 9/21/2020
2.0.3-Preview 4,734 6/30/2020
1.0.1 158,617 6/3/2020
0.4578.0 517,533 4/16/2020
0.4368.1 23,124 3/30/2020
0.3582.0 38,899 2/10/2020
0.3555.1 13,540 1/22/2020
0.3374.11 11,819 1/15/2020
0.3374.10 5,331 12/27/2019
0.3374.9 17,214 11/26/2019
0.3374.4 7,462 10/31/2019
0.3374.1 438 10/25/2019
0.3374.0 397 10/22/2019
Show more
DOCK3
Identifiers
AliasesDOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA
External IDs
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.2Start50,674,927 bp[1]
End51,384,198 bp[1]
Gene location (Mouse)
Chr.Chromosome 9 (mouse)[2]
Band9|9 F1Start106,892,825 bp[2]
End107,231,909 bp[2]
Gene ontology
Molecular function•SH3 domain binding
•GO:0001948 protein binding
•guanyl-nucleotide exchange factor activity
•Rac guanyl-nucleotide exchange factor activity
Cellular component•cytoplasm
•cytosol
Biological process•small GTPase mediated signal transduction
•positive regulation of non-membrane spanning protein tyrosine kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 3: 50.67 – 51.38 MbChr 9: 106.89 – 107.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dock3 (Dedicator of cytokinesis 3), also known as MOCA (modifier of cell adhesion) and PBP (presenilin-binding protein), is a large (~180 kDa) protein involved in intracellularsignalling networks.[5] It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock3 specifically activates the small G protein Rac.

Discovery[edit]

Dock3 was originally discovered in a screen for proteins that bind presenilin (a transmembrane protein which is mutated in early onset Alzheimer's disease).[6] Dock3 is specifically expressed in neurones (primarily in the cerebral cortex and hippocampus).

Structure and function[edit]

Dock3 is part of a large class of proteins (GEFs) which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.

Dock3 exhibits the same domain arrangement as Dock180 (a member of the DOCK-A subfamily and the archetypal member of the DOCK family) and these proteins share a considerable (40%) degree of sequence similarity.[7]

Regulation[edit]

Since Dock3 shares the same domain arrangement as Dock180 it is predicted to have a similar array of binding partners, although this has yet to be demonstrated. It contains an N-terminalSH3 domain, which in Dock180 binds ELMO (a family of adaptor proteins which mediate recruitment and efficient GEF activity of Dock180), and a C-terminalproline-rich region which, in Dock180, binds the adaptor protein CRK.[7][8]

Downstream signalling[edit]

Daisydisk 4 9 download free. Dock3 GEF activity is directed specifically at Rac1. Dock3 has not been shown to interact with Rac3, another Rac protein which is expressed in neuronal cells, and this may be because Rac3 is primarily located in the perinuclear region. Macaw 1 5 15. In fact, Rac1 and Rac3 appear to have distinct and antagonistic roles in these cells.[9] Dock3-mediated Rac1 activation promotes reorganisation of the cytoskeleton in SH-SY5Yneuroblastoma cells and primary cortical neurones as well as morphological changes in fibroblasts.[10] It has also been shown to regulate neurite outgrowth and cell-cell adhesion in B103 and PC12 cells.[11]

In neurological disorders[edit]

The first indication that Dock3 might be involved in neurological disorders came when Dock3 was shown to bind to presenilin, a transmembrane enzyme involved in the generation of beta amyloid (Aβ),[6] accumulation of which is an important step in the development of Alzheimer's disease. Dock3 has been shown to undergo redistribution and association with neurofibrillary tangles in brain samples from patients with Alzheimer's disease.[12] A mutation in Dock3 was also identified in a family displaying a phenotype resembling attention-deficit hyperactivity disorder (ADHD).[13]

References[edit]

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  1. ^ abcGRCh38: Ensembl release 89: ENSG00000088538 - Ensembl, May 2017
  2. ^ abcGRCm38: Ensembl release 89: ENSMUSG00000039716 - Ensembl, May 2017
  3. ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^'Entrez Gene: DOCK3 dedicator of cytokinesis 3'.
  6. ^ abKashiwa A, Yoshida H, Lee S, et al. (July 2000). 'Isolation and characterization of novel presenilin binding protein'. J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID10854253. S2CID24838995.
  7. ^ abCôté JF, Vuori K (December 2002). 'Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity'. J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID12432077.
  8. ^Hasegawa H, Kiyokawa E, Tanaka S, et al. (April 1996). 'DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane'. Mol. Cell. Biol. 16 (4): 1770–76. doi:10.1128/mcb.16.4.1770. PMC231163. PMID8657152.
  9. ^Hajdo-Milasinović A, Ellenbroek SI, van Es S, et al. (February 2007). 'Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells'. J. Cell Sci. 120 (Pt 4): 555–66. doi:10.1242/jcs.03364. PMID17244648.
  10. ^Namekata K, Enokido Y, Iwasawa K, Kimura H (April 2004). 'MOCA induces membrane spreading by activating Rac1'. J. Biol. Chem. 279 (14): 14331–37. doi:10.1074/jbc.M311275200. PMID14718541.
  11. ^Chen Q, Chen TJ, Letourneau PC, et al. (January 2005). 'Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth'. J. Neurosci. 25 (2): 281–90. doi:10.1523/JNEUROSCI.3692-04.2005. PMC6725471. PMID15647471.
  12. ^Chen Q, Yoshida H, Schubert D, et al. (November 2001). 'Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer's Disease and Stimulates Tau Phosphorylation'. Am. J. Pathol. 159 (5): 1567–602. doi:10.1016/S0002-9440(10)63005-2. PMC1867048. PMID11696419.
  13. ^de Silva MG, Elliott K, Dahl HH, et al. (October 2003). 'Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype'. J. Med. Genet. 40 (10): 733–40. doi:10.1136/jmg.40.10.733. PMC1735283. PMID14569117.

Docks V2 0 3d

Further reading[edit]

  • Côté JF, Vuori K (2007). 'GEF what? Dock180 and related proteins help Rac to polarize cells in new ways'. Trends Cell Biol. 17 (8): 383–93. doi:10.1016/j.tcb.2007.05.001. PMC2887429. PMID17765544.
  • Meller N, Merlot S, Guda C (2005). 'CZH proteins: a new family of Rho-GEFs'. J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID16254241.
  • Côté JF, Vuori K (2006). 'In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains'. Meth. Enzymol. Methods in Enzymology. 406: 41–57. doi:10.1016/S0076-6879(06)06004-6. ISBN9780121828110. PMID16472648.
  • Chen Q, Kimura H, Schubert D (2002). 'A novel mechanism for the regulation of amyloid precursor protein metabolism'. J. Cell Biol. 158 (1): 79–89. doi:10.1083/jcb.200110151. PMC2173011. PMID12093789.
  • Brion JP, Anderton BH, Authelet M, et al. (2001). 'Neurofibrillary tangles and tau phosphorylation'(PDF). Biochem. Soc. Symp. 67 (67): 81–88. doi:10.1042/bss0670081. PMID11447842.
  • Kim JM, Lee KH, Jeon YJ, et al. (2007). 'Identification of genes related to Parkinson's disease using expressed sequence tags'. DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID17213182.


Docks V2 0 3 Coils

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